Desilylation Agent | Salego™ DSIL

SACHEM’s Salego™ DSIL line offers a unique product that can be used as desilylation agent or deprotection agent within pharmaceutical multistep synthesis. Salego™ DSIL 3433  (TBAF) is an ideal non-aqueous source of fluoride for organic reaction systems. The use of TBAF as a desilylation or deprotection agent is the most widely known and practiced. However, its unique base and non-nucleophilic properties make it a diverse reagent in multiple reaction classes.

Available Products
Salego™ DSIL 3433
Desilylation agent
Tetrabutylammonium Fluoride (TBAF) Trihydrate, 98%
CAS# 87749-50-6
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Download the whitepaper “Synthetic Utility of TBAF” to review examples of the use of TBAF in deprotection/desilylation chemistry as well as the reactions below:

  • Cyclization
  • Conjugate addition
  • Acylation
  • Alkylation
  • Condensation
  • Elimination


Key Attributes and Benefits of TBAF (desilylation agent)

SACHEM’s TBAF is a desilylation agent offered as a trihydrate crystal which provides the following features:

  • Minimum water content (only 3 mols of water for each mol of TBAF)
  • Easily soluble in organic solvents for increased reactivity in a variety of reaction systems
  • “Anhydrous” source of fluoride (when dissolved and dried in a solvent) for increased accessibility
  • Non-nucleophilic base for use in base-catalyzed reactions
  • Strong desylalition agent for TBDMS (tert-butyldimethylsilyl)-protected alcohols

TBAF Product Availability

Our global network of facilities and seamless logistical support can supply TBAF anywhere in the world, consistently, reliably and at various quantities.

  • Commercial scale manufacturing capability in bulk quantities
  • Packaging of TBAF trihydrate 25 kg and 50 kg fiber drums

Contact us to see how TBAF can work in your reaction system.

"Desilylation Agent | Salego™ DSIL"