SACHEM's Tetrabutylammonium Fluoride (TBAF) is an ideal non-aqueous source of fluoride for organic reaction systems. The use of TBAF as a desilylation or deprotection agent is the most widely known and practiced. However, its unique base and non-nucleophilic properties make it a diverse reagent in multiple reaction classes.

Download the whitepaper "Synthetic Utility of TBAF" to review examples of the use of TBAF in deprotection/desilylation chemistry as well as the reactions below:

• Cyclization
• Conjugate addition
• Acylation
• Alkylation
• Condensation
• Elimination

Synthetic Utility of TBAF

Key Attributes and Features of TBAF

SACHEM offers TBAF as a trihydrate crystal which provides the following features:

• Minimum water content (only 3 mols of water for each mol of TBAF)
• Easily soluble in organic solvents for increased reactivity in a variety of reaction systems
• "Anhydrous" source of fluoride (when dissolved and dried in a solvent) for increased accessibility
• Non-nucleophilic  base for use in base-catalyzed reactions
• Strong desylalition agent for TBDMS (tert-butyldimethylsilyl)-protected alcohols

• Commercial scale manufacturing capability in bulk quantities
• Packaging of TBAF trihydrate 25 kg and 50 kg fiber drums