The Isolis System™ enables significant improvements in impurity profiling, process optimization, quality assurance and bio-comparability.  Isolis™ HIC is SACHEM’s family of displacers for use in hydrophobic interaction chromatography for these types of applications.   They are designed to work with a wide range of hydrophobic interaction chromatography media yet are effectively removed under recommended regeneration conditions.

Advantages of using Isolis™ HIC displacers in high loading displacement mode:

• Removes 90-99% of main component interference without affinity resins or prior knowledge of component identity.
• Impurities are concentrated (10-400X) in discrete zones between main component bands.
• Concentrated impurity zones contain low salt allowing more flexibility in analysis step.

Isolis™ displacers can be used with SACHEM's Regenerate™ reagents.