ISOLIS™ SP
The Isolis System™ enables significant improvements in impurity profiling, process optimization, quality assurance and bio-comparability.  Isolis™ SP is SACHEM’s family of displacers for use in cation exchange chromatography for these types of applications.   They are designed to work with a wide range of cation exchange chromatography media yet are effectively removed under recommended regeneration conditions.

Advantages of using Isolis™ SP displacers in high loading displacement mode:
  • Removes 90-99% of main component interference without affinity resins or prior knowledge of component identity.
  • Impurities are concentrated (10-400X) in discrete zones between main component bands.
  • Concentrated impurity zones contain low salt allowing more flexibility in analysis step.
  • Review Example Results using Isolis™ SP.
To help you get started and learn more about displacement chromatography, SACHEM's Teaching Tools provides example results, a brief tutorial on displacement chromatography and a list of selected publications.

For your convenience, SACHEM's Regenerate™ reagents are designed to work with Isolis™ displacers for column regeneration.