Oligonucleotide purification is especially challenging due to the presence of very similar variants.  This process typically requires high efficiency separation methods such as reverse phase chromatography which presents challenges at the bench scale and beyond.
 

SACHEM'S PROPELL™ DISPLACERS FOR OLIGONUCLEOTIDE PURIFICATION
SACHEM’s Propell™ displacers and displacement chromatography offer a simple way to convert ion exchange analytical columns into effective tools for obtaining large quantities (100+ mg) of purified oligonucleotides in a single run. 

Propell™ displacers are uniquely designed to work effectively in displacement mode yet are still easily removed from chromatography columns. 

Explore how SACHEM can assist in turning your ion exchange analytical columns into serious preparative tools that are simple enough for everyday use.