SACHEM Displacers Highlighted at AICHE 2009 Print E-mail

Austin, TX- October 20, 2009 - An Industrial Case Study demonstrates how displacement chromatography enables industry to better purify and analyze product purity through greater sensitivity and precision in identification of low abundance biomolecules.  Austin, TX- October 20, 2009 - SACHEM's high purity displacers will be discussed at the upcoming AICHE annual conference in Nashville on November, 11, 2009.  The presentation titled, Gram-Scale Isolation of MAb Charge Variants by Displacement Chromatography for Subcutaneous Animal PK Studies is part of a larger session that deals with Advances in Bioseparations and includes papers dealing with bioseparations of biologicals including proteins,peptides, and monoclonal antibodies.

SACHEM's IsolisTM and ExpellTM displacers coupled with displacement chromatography removes 95% of main component interference without affinity resins or prior knowledge of component identity.  The impurities are concentrated (10-400X enrichment) in discrete zones between main component bands.   Not only does displacement help to identify low abundance biomolecules, but it can then be used to quickly scale up and purify larger amounts of the variants for further characterization.


IsolisTM and ExpellTM displacers are pure, well-defined, anionic and cationic organic molecules with low molecular weights allowing their facile removal from biomolecules via dialysis or ultrafiltration if necessary.  "Displacement chromatography is a powerful technique for the purification of proteins and other biomolecules.  These displacers effectively turn small analytical columns into useful preparative tools", said Dr. Barry Haymore, Director of Bioprocessing at SACHEM, Inc. 


SACHEM, Inc delivers highly pure, precise and innovative chemical solutions designed to solve the most demanding and challenging applications.  For over 50 years SACHEM has provided chemical solutions and services to customers in key markets including electronics, advanced ceramics, biotechnology, starch modification, polymers, catalysts, pharmaceutical and agricultural chemicals.  Based in Austin, Texas, SACHEM's expanding worldwide operations include manufacturing and research facilities in North America, Europe and Asia with a global service network and presence spanning over 30 countries. For more information, please visit http://www.sacheminc.com.


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