Expell™ displacers coupled with displacement chromatography enable significant improvements in protein purity and yield in laboratory and large scale production.  Expell™ HIC is SACHEM’s family of displacers for use in hydrophobic interaction chromatography.  They are selectively designed to have the necessary affinity towards hydrophobic interaction chromatography media and can be predictably scaled up from lab to production scale.  Regeneration protocols are provided to effectively and reproducibly remove the displacers from the chromatography column.

Expell™ HIC displacers provide the following benefits when used in high loading displacement mode:

• Protein is displaced off column at high concentration and high purity
• Purified protein contains only loading buffer allowing users to proceed directly to the next step with no additional processing
• Only, the last few fractions of the final component contain Expell™ HIC which can be readily removed via dialysis or ultra filtration.
• This is a reproducible process that scales up reliably.

Expell™ displacers can be used with SACHEM's Regenerate™ reagents.